As the world turns toward increased cultural and commercial integration, it is not clear that humanities programs are sufficiently equipped to engage a global turn in higher education. Furthermore, though “global engagement” has emerged as a buzzword with cache across campus and community organizational missions, the current humanities canon may likewise be ill-equipped to meet the moment. Accordingly, the chapters contained in this volume, which reflect a richly global diversity of authors, themes, and disciplines, critically examine structures that determine the what and how of humanities dissemination worldwide, including technological innovation as well as the dominance of English (-translated) works in the curriculum and the global humanities market. Additionally, we examine blendings of the local and the global, the particular and the universal, the many faces of the cultural other, and possibilities for un-othering in humanities arts and letters, curriculum, and pedagogies.